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| 從增強子調控特徵到癌症治療潛力：PER2在EMT調控中的關鍵角色 | ||||||
| From Enhancer Usage to Therapeutic Insight : PER2 in EMT Regulation | ||||||
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癌症細胞在上皮（epithelial）與間質（mesenchymal）狀態間的轉換，是腫瘤轉移與藥物抗性的重要關鍵，而這一過程往往受到表觀基因體與三維基因組架構的精密調控。針對這一核心問題，由臺大黃韻如教授與中研院黃雯華副研究員共同領導的研究團隊提出假設：不同卵巢癌亞型之間，PER2基因的增強子使用差異，可能正是調控細胞命運的關鍵所在。……。 【閱讀全文】 |
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Epithelial–mesenchymal (EM) plasticity plays a central role in cancer progression, metastasis, and therapy resistance. Understanding how gene regulation contributes to cancer cell state transitions is an ongoing challenge in tumor biology. This study revealed that distinct enhancer usage between epithelial-A (Epi-A) and mesenchymal-like (Mes-like) subtypes of ovarian cancer (OC) underlies differential expression of key regulators of cell state. Among several candidates analyzed, the circadian gene PER2 emerged as a prominent focal point for further investigation. .……. |
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| 創新穩定蛋白之小分子並用於探討龐貝氏症的治療效果 | ||||||
| Discovery of novel protein stabilizers: Study of their efficacy toward Pompe disease | ||||||
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在本計畫中，我們利用由16個分子所組成的多羥基吡咯烷立體異構物分子庫來進行熱轉移分析研究GAA的穩定性。我們從中發現了兩個具有(3S,4S,5S)立體化學特性（L-arabino 類型）的有效分子，隨後通過使用天然產物啟發的組合化學 (NPICC) 進行C2位置的多樣化，並開發出數種D-和L-阿拉伯醣類型的亞胺醣和一個300個分子所組成的分子庫。……。 【閱讀全文】 |
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In this project, we utilized the unique polyhydroxylated pyrrolidine-based in-house chemical library consisting of all sixteen synthetic ADMDP (1-aminodeoxy-DMDP) stereoisomers (structurally covering four chiral centers, three hydroxy groups, one aminomethyl group in each stereoisomer) to study the GAA protein stability via the thermal shift assay. To our delight, two initial hits possessing the (3S,4S,5S) configuration pattern (L-arabino typed), were found. Diversification at the C2 position was performed by using natural product-inspired combinatorial chemistry (NPICC) to develop several D- and L-arabino typed iminosugars and a 300-membered amide Library. .……. |
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| 壓電刺激在神經調節之研究 | ||||||
| Investigation of piezoelectric stimulation for neuromodulation | ||||||
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本研究探討壓電特性在生理上所扮演的角色，特別是壓電刺激對骨骼相關細胞與神經細胞的影響，並基於所發現的特定作用轉譯設計適當的壓電醫材或療程。我們發現壓電刺激能有效促進骨髓幹細胞的遷移與分化，也影響軟骨細胞的極性與排列，這些細胞特性都和骨癒合息息相關，意即壓電刺激極可能促進骨癒合。……。 【閱讀全文】 |
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This study explores the role of piezoelectricity in physiology, in particular the influence of piezoelectric stimulation on cells in skeletal systems and neurons. The aim is to identify unique effects of piezoelectric stimulation for possible translation into clinical applications. Here we found that piezoelectric stimulation can facilitate migration and chondrogenesis of bone marrow derived stem cells. It also affects cell polarity and rearrangement of chondrocytes. All of these are relevant to bone fracture healing. In other words, piezoelectric stimulation could help facilitate fracture healing. ……. |
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